Evaluation of Some Novel Techniques For Dissolution Enhancement of Poorly Water Soluble Drug Nimodipine

Nimodipine (NMP), a Ca channel blocker, has a low oral bioavailability due to poor solubility and insufficient dissolution rate. In order to improve the same, various techniques were employed viz., evaporative precipitation into aqueous solution (EPAS), spherical agglomeration (SA) and solid dispersion using solvent evaporation and meltmixing. Formulations so prepared were characterised by differential scanning calorimetry (DSC) and X-Ray powder diffractometry (XRD) and were investigated for drug content studies, solubility studies, in-vitro study and in vivo evaluation of anti-inflammatory activity. The formulations of NMP prepared by spherical agglomeration technique have the good drug content and the formulations with SLS and HPMC show a significant increase in solubility in case of SA technique. In case of solid dispersion, all carriers show improvement in the dissolution rate of the drug The DSC studies show no change in the polymorphism in most of the formulations The XRD studies of the formulations show no change in their crystalline form..